Biological Pathways Associated with Neuroprogression in Bipolar Disorder
نویسندگان
چکیده
منابع مشابه
[Bipolar disorder: staging and neuroprogression].
In bipolar disorder illness progression has been associated with a higher number of mood episodes and hospitalizations, poorer response to treatment, and more severe cognitive and functional impairment. This supports the notion of the use of staging models in this illness. The value of staging models has long been recognized in many medical and malignant conditions. Staging models rely on the f...
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Many psychiatric disorders, including bipolar disorder follow a progressive path, and manifest a variable but observable trajectory. While Kraepelin (1921) described a progressive dementing process in schizophrenia, and conceptualized the illness as a stepwise, progressive disorder, he saw bipolar disorder as having a more episodic pattern. Nevertheless, it has become clear that bipolar disorde...
متن کاملVirginia Woolf, neuroprogression, and bipolar disorder.
Family history and traumatic experiences are factors linked to bipolar disorder. It is known that the lifetime risk of bipolar disorder in relatives of a bipolar proband are 5-10% for first degree relatives and 40-70% for monozygotic co-twins. It is also known that patients with early childhood trauma present earlier onset of bipolar disorder, increased number of manic episodes, and more suicid...
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There is now strong evidence of progressive neuropathological processes in bipolar disorder (BD). On this basis, the current understanding of the neurobiology of BD has shifted from an initial focus on monoamines, subsequently including evidence of changes in intracellular second messenger systems and more recently to, incorporating changes in inflammatory cytokines, corticosteroids, neurotroph...
متن کاملCytokines in Bipolar Disorder: Paving the Way for Neuroprogression
Bipolar disorder (BD) is a severe, chronic, and recurrent psychiatric illness. It has been associated with high prevalence of medical comorbidities and cognitive impairment. Its neurobiology is not completely understood, but recent evidence has shown a wide range of immune changes. Cytokines are proteins involved in the regulation and the orchestration of the immune response. We performed a rev...
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ژورنال
عنوان ژورنال: Brain Sciences
سال: 2021
ISSN: 2076-3425
DOI: 10.3390/brainsci11020228